March Madness parlays can bring even more excitement to arguably the biggest event on the sports betting calendar. With so many games happening in such a short time period, picking the best legs for your NCAA parlays can be easier said than done, though.
Luckily, The Sports Geek team is ready to give you a helping hand. We have searched high and low for the best legs to add to our daily March Madness parlays. Check back here daily to see the best parlay for every day of the NCAA Tournament.
Best March Madness Parlay Picks for March 21
Here are our March Madness parlay picks for March 21, using odds courtesy of Bovada.
| Match | Selection | Odds |
|---|---|---|
| #12 Colorado State vs. #5 Memphis | Memphis Tigers +1.5 | -110 |
| #16 Mount St. Mary’s vs. #1 Duke | Mount St. Mary’s Mountaineers +32.0 | -110 |
| #14 Troy vs. #3 Kentucky | Troy Trojans +11.0 | -105 |
| Total | +612 |
Parlay Leg 1: #12 Colorado State vs. #5 Memphis (+1.5)
The #5 Memphis Tigers won The American conference and earned a fifth seed in March Madness. Despite that, the Tigers are among the few higher-seeded teams that are underdogs in the first round. Memphis is getting 1.5 points for their opening-round game against #12 Colorado State.
Andy Katz ranks the top 🔟 players appearing in #MarchMadness 🔥 pic.twitter.com/Aqe4njYvrv
— NCAA March Madness (@MarchMadnessMBB) March 19, 2025
Memphis Senior guard Tyrese Hunter is in danger of missing this matchup due to a left foot injury. The Tigers won The American conference without Hunter, but they need him to make a deep run this March.
Colorado State, on the other hand, has won 10 straight games, including a Mountain West conference title. Senior guard Nique Clifford, averaging 19.0 points, 9.7 rebounds, and 3.3 assists per game, has been key to the Rams’ success.
The odds are stacked against Memphis, but the Tigers are a deeper team than Colorado State. They also still have guard PJ Haggerty (21.8 PPG) and should upset the lower-seeded Rams.
Leg 2: #16 Mount St. Mary’s (+32.0) vs. #1 Duke
Another underdog in my best parlay bets for March Madness is #16 Mount St. Mary’s. The Mountaineers took down American 83-72 in their First Four matchup to earn their spot in Round One.
March Madness betting sites list Mount St. Mary’s as a 32.0-point underdog against Duke. The Blue Devils were a top-15 offense this year, averaging 82.7 PPG. However, Duke could be without superstar Cooper Flagg. Flagg may miss the game due to a sprained ankle.
Even if Flagg plays, he could be limited by the injury. Duke should beat the Mountaineers with or without Flagg. However, thanks to his injury, I believe Mount St. Mary’s can cover the 32.0-point spread.
Duke’s defense only allowed 61.9 PPG, the seventh-fewest in Men’s college basketball, but the Mountaineers only allowed 69.9 PPG, so this could be a low-scoring game. If you add Flagg’s injury and the massive spread, backing the underdog makes a lot of sense here.
Leg 3: #14 Troy (+11.0) vs. #3 Kentucky
The third leg of my best March Madness parlay today is for #14 Troy (+11.0) to cover the spread against #3 Kentucky Wildcats. Kentucky’s recent struggles in the NCAA Tournament have made the Wildcats a popular upset pick in Round One.
📍 THEY'RE IN.
No. 3 @KentuckyMBB vs. No. 14 Troy
Fri., March 21 • Milwaukee (Midwest Region)@MarchMadnessMBB x #ItJustMeansMore pic.twitter.com/3gCUHa01PH— Southeastern Conference (@SEC) March 16, 2025
This is the third time in the last four years that the Wildcats have been a top-three seed. In 2022 and 2023, they lost in the first round to #15 St. Peter’s and #14 Oakland, respectively.
Every tournament is unique, and Kentucky can silence the doubters with a win over Troy. The Wildcats have the advantage on offense, outscoring the Trojans 85.3 to 73.9 on a PPG basis. However, Troy’s defense is better, allowing 65.4 PPG to Kentucky’s 77.9.
The Trojans’ defense will be tested, but I believe they will keep this game within 10 points. Kentucky should win, but covering the spread is a different story.
Best Betting Site for March Madness Parlays
Where you bet on your parlay can be as important as the individual legs you decide to wager on. Luckily, sites like Bovada make it easy to handcraft the best parlay bets for March Madness.
Bovada offers dozens of markets with competitive odds for all games of the NCAA Tournament. It also has fantastic welcome bonus options, such as a deposit match worth up to $1,000 when you use the code BV1000.
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