March Madness 2025 Betting Odds and Predictions – Duke Favored in #1 Seed Final Four Party

March Madness 2025 Betting Odds and Predictions – Duke Favored in #1 Seed Final Four Party

The 2025 March Madness betting odds have been somewhat steady since the start of the men’s NCAA Division 1 Tournament. All four #1 seeds made it to the Final Four, so picking the winner is tough!

I’ll take a look at the NCAA championship odds for the 2024-2025 season, and break down all remaining teams Then, I’ll give you my March Madness predictions at the end of this article!

2024-2025 NCAA Championship Odds

The following men’s March Madness odds are courtesy of Bovada:

Heading into the Final Four, the March Madness odds have settled on the #1 seeds. Duke (-110) continue to be the favorites, as they have been all tournament long! The Blue Devils moved from +220 ahead of the Sweet 16 to the current odds, and now have a 52.4% implied win probability, an increase from 31.3% a week ago. Florida (+275) is next with a 26.7% implied win chance, which is up from 21.1%.

Houston (+425) was +500 last week but increased their chances after a series of impressive performances. Auburn (+550) brings up the rear, but they’re as dangerous as anyone, and they came into the NCAA Tournament as the #1 overall seed! The Cougars have a 19.1% implied win chance, while the Tigers come in at 15.4%.

This is the first time since 2008 that all four #1 seeds made it to the Final Four, and only the second time since the Tournament expanded to 64 teams. We’re in for a really fun Final Four weekend!

You can find these NCAA Tournament odds at Bovada by going to Sports > Basketball > College Basketball Futures > Men’s Basketball Tournament.  

Top March Madness 2025 Favorites

Let’s tip things off by looking at the favorites in this season’s March Madness odds!

Duke Blue Devils (-110)

The Blue Devils ran through the East Region, winning their four games by an average of 31.3 points! With the exception of a 100-93 win over Arizona in the Elite 8, the Blue Devils have handled their competition with relative ease.

Cooper Flagg won the Most Outstanding Player of the East Region, shaking off an early ankle injury. But the Blue Devils are much more than their star player. Tyrese Proctor led Duke in points over the first two games, then Flagg put up 30 against Arizona when Duke needed him most. Kon Knueppel had 21 points, five rebounds, five assists, and three steals as the Blue Devils shut down Alabama’s high-powered offense.

Khaman Maluach has provided incredible rim protection for the Blue Devils, blocking eight shots over the last three games, and altering many more. The freshman has also added scoring down low, hitting a remarkable 87% of his shots in the NCAA Tournament.

If there is a concern about Duke, it’s that four of their top six players are freshmen, outside of Proctor and Sion James. But the pressure doesn’t seem to get to the Blue Devils, and I don’t think it’ll be a factor in the Final Four and beyond. I’m not surprised at the Duke price heading into the Final Four, and they’re favored over Houston as the two prepare to meet in San Antonio on Saturday!


Road to the Final

  • W – 95-49 vs. #16 Mount St. Mary’s
  • W – 89-66 vs. #9 Baylor
  • W – 100-93 vs. #4 Arizona
  • W – 85-65 vs. #2 Alabama

The Blue Devils will face their toughest test in the Final Four against Houston, but they handled a really good Alabama team very easily with their defense. They’re the most talented team left, but can Duke fulfill the prophecy and make it to the title game next Monday?

Florida Gators (+275)

It hasn’t been easy for the Gators, who emerged out of the West Region. They routed Norfolk State in the first round, then needed a late flurry from Walter Clayton Jr. to end UConn’s bid for a three-peat, winning 77-75.

The Gators wore down Maryland for an 87-71 win, but Florida required heroics from Clayton Jr. once again in an 84-79 victory over Texas Tech. That win sealed Florida’s sixth Final Four, and their first since 2014.

Clayton Jr., who joined Flagg on the All-America first team, has been brilliant, averaging 22.3 points, and hitting 45.2% of his three-point attempts. The Gators have a knack for going on offensive runs, and Clayton Jr. is at the heart of that. Florida is also experienced as their top three players are seniors, and it has shown as the Gators don’t get flustered when their opposition makes a run.

Florida will be happy to have a few days off as sophomore forward Alex Condon injured his ankle in the first half of the Maryland game. He returned in the second half and played well and gave the Gators 28 good minutes with seven points, seven rebounds, a block and two steals.

Florida’s guard trio of Clayton Jr., Alijah Martin, and Will Richard get the attention, but Condon’s size and physicality is key to Florida’s chances at college basketball betting sites.

The Gators are favored over Auburn in their Final Four matchup. Florida already has the edge as they beat the Tigers 90-81 on the road on February 8 as 10-point underdogs. Can they do the double over Auburn, but as the Final Four odds favorites this time?


Road to the Final

  • W – 95-69 vs. #16 Norfolk State
  • W – 77-75 vs. #8 UConn
  • W – 87-71 vs. # 4 Maryland
  • W – 84-79 vs. #3 Texas Tech

The Gators have overcome some adversity, and actually had to come back against Texas Tech. But they’re well-placed to make it to the final, playing an Auburn team they’ve already beaten from a tougher position.

2024-2025 March Madness Odds Sleepers

Next, let’s check out the odds to win the NCAA championship for a couple of sleepers, although they still have great 2025 NCAA Tournament odds!

Houston Cougars (+425)

The Cougars rode their top-ranked defense through the Midwest Region, allowing an average of 56.5 points. After rolling over SIU Edwardsville, Houston held off Gonzaga for an 81-76 win, which constitutes a shootout for the Cougars! Houston then beat Purdue 62-60 on one of the nicest inbound plays you’ll ever see, before trouncing Tennessee in the Elite 8.

I’ve been high on the Cougars and their NCAA Tournament odds, thanks to their stifling defense, and they have a player that can get a bucket when it is needed. That’s L.J. Cryer, who made the All-America third team. Cryer tied a career high with 30 points against Gonzaga, and he is averaging 16.8 points in the Tournament. The senior guard has also hit 39.4% of his three-pointers.

The Cougars are underdog going into their showdown against Duke, but they shouldn’t be overlooked. While the Blue Devils are led by freshmen, five of Houston’s top six are seniors or juniors. The Cougars were also in the 2021 Final Four, so they won’t be afraid of the moment. Currently, I’m leaning towards Duke in the matchup, but a win for Houston shouldn’t shock anyone at all!


Road to the Final

  • W – 78-40 vs. #16 SIU Edwardsville
  • W – 81-76 vs. #8 Gonzaga
  • W – 62-60 vs. #4 Purdue
  • W – 69-50 vs. #2 Tennessee

The Cougars have shown they can win a relatively high-scoring game against the Bulldogs, but they’re going to want to make it an ugly game against Duke, who can hurt them many ways offensively.

Auburn Tigers (+550)

The Tigers got through the South Region, but they haven’t overwhelmed as the other three teams have. They beat Alabama State by 20, then Creighton by 12, Michigan by 13, and Michigan State by six points.

All that matters is that you survive and advance, and the Tigers did that to reach their second Final Four, and first since 2019. That set off a wild celebration at Toomers Corner, which is usually reserved for big football wins.

Senior forward Johni Broome has averaged 17.3 points and 13.3 rebounds, and shook off an arm injury against Michigan State to post 25 points and 14 boards. The Tigers have also gotten big games from their guards, freshman Tahaad Pettiford and senior Miles Kelly. Auburn has definitely stepped up their defense from the regular season, allowing 65.5 points per game.

They’ll need that to continue against Florida, who put up 90 points on them at Auburn. The Tigers will also hope that Broome’s arm is fine because they’ll need him to dominate against Florida. Broome had 18 points, 11 rebounds, six assists, and two blocks in the first game.

Auburn will need more from the first team All-American if they’re going to reach the national title game. I think the Tigers are properly priced heading into Final Four weekend, but with an implied probability of 15.4%, there is certainly a shot of Auburn winning their first NCAA Tournament! 


Road to the Final

  • W – 83-63 vs. #16 Alabama State
  • W – 82-70 vs. #9 Creighton
  • W – 78-65 vs. #5 Michigan
  • W – 70-64 vs. #2 Michigan State

The Tigers have gotten by so far in the NCAA Tournament, but they’ll need to bring their A-game if they want to avoid a second loss to Florida this season

2024-25 NCAA Basketball Championship Predictions

I think the 2025 March Madness odds for these teams are priced in the proper order, but there is a world in which any of these four can win it all! They’re deserving of their #1 seeds for a reason, and they’ve all proved it throughout the NCAA Tournament so far.

Despite the lack of experience, I can’t look past Duke at -110. This price could skew more towards the Blue Devils as the week goes on. They have the best player in the country in Flagg, and they’re excellent on both ends of the floor. I was really impressed with their defense against an Alabama team that set a three-point record against BYU in the Sweet 16.

They have size, versatility, courage, rim protection, and Cooper Flagg. I’m still sticking with Duke at -110 in my March Madness predictions!

The Bet
Duke Blue Devils

Who’s Winning March Madness 2025?

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About the Author
Finn Archer profile picture
Finn Archer
Editor, Sports and Casino
Finn is a writer with 4+ years of experience publishing articles under the pseudonym Phil Bowman. He’s also a longtime sports enthusiast and bettor with a strong passion for soccer. That said, he’ll dabble in anything involving a ball, bat, or boxing gloves! His writing mainly focuses on helping bettors learn from their mistakes and gamble responsibly. Finn currently lives in Europe.
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