NFL

San Francisco 49ers @ Buffalo Bills - December 1, 2024

November 26, 2024, 9:53am EST

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SPREAD PICK

San Francisco 49ers

-1.5

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$

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-1.5

-120

MONEYLINE PICK

San Francisco 49ers

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$

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sfo

+152

OVER/UNDER PICK

Over

47.5

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47.5

-120

As a retired coach with years of experience dissecting the intricacies of the game, I can tell you that Sunday’s matchup between the San Francisco 49ers and the Buffalo Bills at Highmark Stadium is shaping up to be a compelling clash. With both teams vying for a crucial win, there are plenty of dynamics at play that will influence how this game unfolds.

First off, let’s consider the records: Buffalo comes in with an impressive 9-2 record, riding high on a six-game winning streak. Their offense has been firing on all cylinders, averaging just over 29 points per game. They’ve demonstrated balance with an effective passing attack—over 231 yards per game—and a solid ground game averaging about 119 yards. Their completion percentage hovers around 65%, which indicates efficiency and precision in their aerial assault.

On the flip side, we have San Francisco sitting at 5-6. The 49ers have struggled lately, going just 1-4 against the spread in their last five games and losing by significant margins—most recently falling to Green Bay by a score of 38-10. They average around 23 points per game but boast slightly better passing stats than Buffalo with an average of over 255 passing yards per contest and a similar completion percentage. However, they’ll need to capitalize on their rushing attack (about 138 yards) if they hope to keep pace with Buffalo’s high-octane offense.

When analyzing team dynamics and strategies from my coaching days, one thing stands out: momentum matters. The Bills have built confidence through their recent performances; they’re not just winning—they’re covering spreads effectively as well (5-1 ATS in their last six). Conversely, San Francisco’s road woes (2-4 SU in their last six games away from home) raise red flags about their ability to compete under pressure.

Defensively, both teams will need to step up. While Buffalo has shown resilience on defense throughout the season—particularly during their recent stretch—their challenge will be containing San Francisco’s run game while forcing them into predictable passing situations. For San Francisco’s defense, stopping Buffalo’s explosive plays will be paramount; if they can limit big gains and force some turnovers, they might just find themselves back in contention.

Looking ahead to our predictions for this matchup: I believe that despite San Francisco being underdogs and having struggles on the road, they’ll manage to pull off an upset against Buffalo while also covering the spread due to sheer determination and strategic adjustments made during practice leading up to this week. I expect it to be a high-scoring affair as both offenses display their capabilities—thus making it likely that we see totals surpassing the set line of 47.5 points.

In summary, expect an exhilarating battle filled with tactical maneuvers as both head coaches try to outsmart each other. While my heart says one thing based on past experiences coaching teams through adversity—the numbers suggest another outcome entirely—but sometimes it’s those unexpected moments that define a season! So tune in; this is one matchup you won’t want to miss!

Buffalo Bills vs San Francisco 49ers
Live Odds & Betting History

Betting odds provided by BetUS

Wager TypeBuffalo BillsSan Francisco 49ers
Spread+1.5 (-120) -1.5 (-120)
Moneyline-180+152
TotalUnder 47.5 (-120)Over 47.5 (-120)
Team DataBuffalo BillsSan Francisco 49ers
Points Scored29.0923.64
Passing Yards231.64255.64
Pass Completions %64.57%65.26%
Rushing Yards119.18138.36
Rushing Yards per Attampt7.558.41
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